Questions and Answers ​in MRI
  • Home
  • Complete List of Questions
  • …Magnets & Scanners
    • Basic Electromagnetism >
      • What causes magnetism?
      • What is a Tesla?
      • Who was Tesla?
      • What is a Gauss?
      • How strong is 3.0T?
      • What is a gradient?
      • Aren't gradients coils?
      • What is susceptibility?
      • How to levitate a frog?
      • What is ferromagnetism?
      • Superparamagnetism?
    • Magnets - Part I >
      • Types of magnets?
      • Brands of scanners?
      • Which way does field point?
      • Which is the north pole?
      • Low v mid v high field?
      • Advantages to low-field?
      • Disadvantages?
      • What is homogeneity?
      • Why homogeneity?
      • Why shimming?
      • Passive shimming?
      • Active shimming?
    • Magnets - Part II >
      • Superconductivity?
      • Perpetual motion?
      • How to ramp?
      • Superconductive design?
      • Room Temp supercon?
      • Liquid helium use?
      • What is a quench?
      • Is field ever turned off?
      • Emergency stop button?
    • Gradients >
      • Gradient coils?
      • How do z-gradients work?
      • X- and Y- gradients?
      • Open scanner gradients?
      • Eddy current problems?
      • Active shielded gradients?
      • Active shield confusion?
      • What is pre-emphasis?
      • Gradient heating?
      • Gradient specifications?
      • Gradient linearity?
    • RF & Coils >
      • Many kinds of coils?
      • Radiofrequency waves?
      • Phase v frequency?
      • RF Coil function(s)?
      • RF-transmit coils?
      • LP vs CP (Quadrature)?
      • Multi-transmit RF?
      • Receive-only coils?
      • Array coils?
      • AIR Coils?
    • Site Planning >
      • MR system layout?
      • What are fringe fields?
      • How to reduce fringe?
      • Magnetic shielding?
      • Need for vibration testing?
      • What's that noise?
      • Why RF Shielding?
      • Wires/tubes thru wall?
  • ...Safety and Screening
    • Overview >
      • ACR Safety Zones?
      • MR safety screening?
      • Incomplete screening?
      • Passive v active implants?
      • Conditional implants?
      • Common safety issues?
      • Projectiles?
      • Metal detectors?
      • Pregnant patients?
      • Postop, ER & ICU patients?
      • Temperature monitoring?
      • Orbital foreign bodies?
      • Bullets and shrapnel?
    • Static Fields >
      • "Dangerous" metals?
      • "Safe" metals?
      • Magnetizing metal?
      • Object shape?
      • Forces on metal?
      • Most dangerous place?
      • Force/torque testing?
      • Static field bioeffects?
      • Dizziness/Vertigo?
      • Flickering lights?
      • Metallic taste?
    • RF Fields >
      • RF safety overview?
      • RF biological effects?
      • What is SAR?
      • SAR limits?
      • Operating modes?
      • How to reduce SAR?
      • RF burns?
      • Estimate implant heating?
      • SED vs SAR?
      • B1+rms vs SAR?
      • Personnel exposure?
      • Cell phones?
    • Gradient Fields >
      • Gradient safety overview
      • Acoustic noise?
      • Nerve stimulation?
      • Gradient vs RF heating?
    • Safety: Neurological >
      • Aneurysm coils/clips?
      • Shunts/drains?
      • Pressure monitors/bolts?
      • Deep brain stimulators?
      • Spinal cord stimulators?
      • Vagal nerve stimulators?
      • Cranial electrodes?
      • Carotid clamps?
      • Peripheral stimulators?
      • Epidural catheters?
    • Safety: Head & Neck >
      • Additional orbit safety?
      • Cochlear Implants?
      • Bone conduction implants?
      • Other ear implants?
      • Dental/facial implants?
      • ET tubes & airways?
    • Safety: Chest & Vascular >
      • Breast tissue expanders?
      • Breast biopsy markers?
      • Airway stents/valves/coils?
      • Respiratory stimulators?
      • Ports/vascular access?
      • Swan-Ganz catheters?
      • IVC filters?
      • Implanted infusion pumps?
      • Insulin pumps & CGMs?
      • Vascular stents/grafts?
      • Sternal wires/implants?
    • Safety: Cardiac >
      • Pacemaker dangers?
      • Pacemaker terminology?
      • New/'Safe" Pacemakers?
      • Old/Legacy Pacemakers?
      • Violating the conditions?
      • Epicardial pacers/leads?
      • Cardiac monitors?
      • Heart valves?
      • Miscellaneous CV devices?
    • Safety: Abdominal >
      • PIllCam and capsules?
      • Gastric pacemakers?
      • Other GI devices?
      • Contraceptive devices?
      • Foley catheters?
      • Incontinence devices?
      • Penile Implants?
      • Sacral nerve stimulators?
      • GU stents and other?
    • Safety: Orthopedic >
      • Orthopedic hardware?
      • External fixators?
      • Traction and halos?
      • Bone stimulators?
      • Magnetic rods?
  • …The NMR Phenomenon
    • Spin >
      • What is spin?
      • Why I = ½, 1, etc?
      • Proton = nucleus = spin?
      • Predict nuclear spin (I)?
      • Magnetic dipole moment?
      • Gyromagnetic ratio (γ)?
      • "Spin" vs "Spin state"?
      • Energy splitting?
      • Fall to lowest state?
      • Quantum "reality"?
    • Precession >
      • Why precession?
      • Who was Larmor?
      • Energy for precession?
      • Chemical shift?
      • Net magnetization (M)?
      • Does M instantly appear?
      • Does M also precess?
      • Does precession = NMR?
    • Resonance >
      • MR vs MRI vs NMR?
      • Who discovered NMR?
      • How does B1 tip M?
      • Why at Larmor frequency?
      • What is flip angle?
      • Spins precess after 180°?
      • Phase coherence?
      • Release of RF energy?
      • Rotating frame?
      • Off-resonance?
      • Adiabatic excitation?
      • Adiabatic pulses?
    • Relaxation - Physics >
      • Bloch equations?
      • What is T1?
      • What is T2?
      • Relaxation rate vs time?
      • Why is T1 > T2?
      • T2 vs T2*?
      • Causes of Relaxation?
      • Dipole-dipole interactions?
      • Chemical Exchange?
      • Spin-Spin interactions?
      • Macromolecule effects?
      • Which H's produce signal?
      • "Invisible" protons?
      • Magnetization Transfer?
      • Bo effect on T1 & T2?
      • How to predict T1 & T2?
    • Relaxation - Clincial >
      • T1 bright? - fat
      • T1 bright? - other oils
      • T1 bright? - cholesterol
      • T1 bright? - calcifications
      • T1 bright? - meconium
      • T1 bright? - melanin
      • T1 bright? - protein/mucin
      • T1 bright? - myelin
      • Magic angle?
      • MT Imaging/Contrast?
  • …Pulse Sequences
    • MR Signals >
      • Origin of MR signal?
      • Free Induction Decay?
      • Gradient echo?
      • TR and TE?
      • Spin echo?
      • 90°-90° Hahn Echo?
      • Stimulated echoes?
      • STEs for imaging?
      • 4 or more RF-pulses?
      • Partial flip angles?
      • How is signal higher?
      • Optimal flip angle?
    • Spin Echo >
      • SE vs Multi-SE vs FSE?
      • Image contrast: TR/TE?
      • Opposite effects ↑T1 ↑T2?
      • Meaning of weighting?
      • Does SE correct for T2?
      • Effect of 180° on Mz?
      • Direction of 180° pulse?
    • Inversion Recovery >
      • What is IR?
      • Why use IR?
      • Phase-sensitive IR?
      • Why not PSIR always?
      • Choice of IR parameters?
      • TI to null a tissue?
      • STIR?
      • T1-FLAIR
      • T2-FLAIR?
      • IR-prepped sequences?
      • Double IR?
    • Gradient Echo >
      • GRE vs SE?
      • Multi-echo GRE?
      • Types of GRE sequences?
      • Commercial Acronyms?
      • Spoiling - what and how?
      • Spoiled-GRE parameters?
      • Spoiled for T1W only?
      • What is SSFP?
      • GRASS/FISP: how?
      • GRASS/FISP: parameters?
      • GRASS vs MPGR?
      • PSIF vs FISP?
      • True FISP/FIESTA?
      • FIESTA v FIESTA-C?
      • DESS?
      • MERGE/MEDIC?
      • GRASE?
      • MP-RAGE v MR2RAGE?
    • Susceptibility Imaging >
      • What is susceptibility (χ)?
      • What's wrong with GRE?
      • Making an SW image?
      • Phase of blood v Ca++?
      • Quantitative susceptibility?
    • Diffusion: Basic >
      • What is diffusion?
      • Iso-/Anisotropic diffusion?
      • "Apparent" diffusion?
      • Making a DW image?
      • What is the b-value?
      • b0 vs b50?
      • Trace vs ADC map?
      • Light/dark reversal?
      • T2 "shine through"?
      • Exponential ADC?
      • T2 "black-out"?
      • DWI bright causes?
    • Diffusion: Advanced >
      • Diffusion Tensor?
      • DTI (tensor imaging)?
      • Whole body DWI?
      • Readout-segmented DWI?
      • Small FOV DWI?
      • IVIM?
      • Diffusion Kurtosis?
    • Fat-Water Imaging >
      • Fat & Water properties?
      • F-W chemical shift?
      • In-phase/out-of-phase?
      • Best method?
      • Dixon method?
      • "Fat-sat" pulses?
      • Water excitation?
      • STIR?
      • SPIR?
      • SPAIR v SPIR?
      • SPIR/SPAIR v STIR?
  • …Making an Image
    • From Signals to Images >
      • Phase v frequency?
      • Angular frequency (ω)?
      • Signal squiggles?
      • Real v Imaginary?
      • Fourier Transform (FT)?
      • What are 2D- & 3D-FTs?
      • Who invented MRI?
      • How to locate signals?
    • Frequency Encoding >
      • Frequency encoding?
      • Receiver bandwidth?
      • Narrow bandwidth?
      • Slice-selective excitation?
      • SS gradient lobes?
      • Cross-talk?
      • Frequency encode all?
      • Mixing of slices?
      • Two slices at once?
      • Simultaneous Multi-Slice?
    • Phase Encoding >
      • Phase-encoding gradient?
      • Single PE step?
      • What is phase-encoding?
      • PE and FE together?
      • 2DFT reconstruction?
      • Choosing PE/FE direction?
    • Performing an MR Scan >
      • What are the steps?
      • Automatic prescan?
      • Routine shimming?
      • Coil tuning/matching?
      • Center frequency?
      • Transmitter gain?
      • Receiver gain?
      • Dummy cycles?
      • Where's my data?
      • MR Tech qualifications?
    • Image Quality Control >
      • Who regulates MRI?
      • Who accredits?
      • Mandatory accreditation?
      • Routine quality control?
      • MR phantoms?
      • Geometric accuracy?
      • Image uniformity?
      • Slice parameters?
      • Image resolution?
      • Signal-to-noise?
      • Ghosting?
  • …K-space & Rapid Imaging
    • K-space (Basic) >
      • What is k-space?
      • Parts of k-space?
      • What does "k" stand for?
      • Spatial frequencies?
      • Locations in k-space?
      • Data for k-space?
      • Why signal ↔ k-space?
      • Spin-warp imaging?
      • Big spot in middle?
      • K-space trajectories?
      • Radial sampling?
    • K-space (Advanced) >
      • K-space grid?
      • Negative frequencies?
      • Field-of-view (FOV)
      • Rectangular FOV?
      • Partial Fourier?
      • Phase symmetry?
      • Read symmetry?
      • Why not use both?
      • ZIP?
    • Rapid Imaging (FSE &EPI) >
      • What is FSE/TSE?
      • FSE parameters?
      • Bright Fat?
      • Other FSE differences?
      • Dual-echo FSE?
      • Driven equilibrium?
      • Reduced flip angle FSE?
      • Hyperechoes?
      • SPACE/CUBE/VISTA?
      • Echo-planar imaging?
      • HASTE/SS-FSE?
    • Parallel Imaging (PI) >
      • What is PI?
      • How is PI different?
      • PI coils and sequences?
      • Why and when to use?
      • Two types of PI?
      • SENSE/ASSET?
      • GRAPPA/ARC?
      • CAIPIRINHA?
      • Compressed sensing?
      • Noise in PI?
      • Artifacts in PI?
  • …Contrast Agents
    • Contrast Agents: Physics >
      • Why Gadolinium?
      • Paramagnetic relaxation?
      • What is relaxivity?
      • Why does Gd shorten T1?
      • Does Gd affect T2?
      • Gd & field strength?
      • Best T1-pulse sequence?
      • Triple dose and MT?
      • Dynamic CE imaging?
      • Gadolinium on CT?
    • Contrast Agents: Clinical >
      • So many Gd agents!
      • Important properties?
      • Ionic v non-ionic?
      • Intra-articular/thecal Gd?
      • Gd liver agents (Eovist)?
      • Mn agents (Teslascan)?
      • Feridex & Liver Agents?
      • Lymph node agents?
      • Ferumoxytol?
      • Blood pool (Ablavar)?
      • Bowel contrast agents?
    • Contrast Agents: Safety >
      • Gadolinium safety?
      • Allergic reactions?
      • Renal toxicity?
      • What is NSF?
      • NSF by agent?
      • Informed consent for Gd?
      • Gd protocol?
      • Is Gd safe in infants?
      • Reduced dose in infants?
      • Gd in breast milk?
      • Gd in pregnancy?
      • Gd accumulation?
      • Gd deposition disease?
  • …Cardiovascular and MRA
    • Flow effects in MRI >
      • Defining flow?
      • Expected velocities?
      • Laminar v turbulent?
      • Predicting MR of flow?
      • Time-of-flight effects?
      • Spin phase effects?
      • Flow void?
      • Why GRE ↑ flow signal?
      • Slow flow v thrombus?
      • Even-echo rephasing?
      • Flow-compensation?
      • Flow misregistration?
    • MR Angiography - I >
      • MRA methods?
      • Dark vs bright blood?
      • Time-of-Flight (TOF) MRA?
      • 2D vs 3D MRA?
      • MRA parameters?
      • Magnetization Transfer?
      • Ramped flip angle?
      • MOTSA?
      • Fat-suppressed MRA?
      • TOF MRA Artifacts?
      • Phase-contrast MRA?
      • What is VENC?
      • Measuring flow?
      • 4D Flow Imaging?
      • How accurate?
    • MR Angiography - II >
      • Gated 3D FSE MRA?
      • 3D FSE MRA parameters?
      • SSFP MRA?
      • Inflow-enhanced SSFP?
      • MRA with ASL?
      • Other MRA methods?
      • Contrast-enhanced MRA?
      • Timing the bolus?
      • View ordering in MRA?
      • Bolus chasing?
      • TRICKS or TWIST?
      • CE-MRA artifacts?
    • Cardiac I - Intro/Anatomy >
      • Cardiac protocols?
      • Patient prep?
      • EKG problems?
      • Magnet changes EKG?
      • Gating v triggering?
      • Gating parameters?
      • Heart navigators?
      • Dark blood/Double IR?
      • Why not single IR?
      • Triple IR?
      • Polar plots?
      • Coronary artery MRA?
    • Cardiac II - Function >
      • Beating heart movies?
      • Cine parameters?
      • Real-time cine?
      • Ventricular function?
      • Tagging/SPAMM?
      • Perfusion: why and how?
      • 1st pass perfusion?
      • Quantifying perfusion?
      • Dark rim artifact
    • Cardiac III - Viability >
      • Gd enhancement?
      • TI to null myocardium?
      • PS (phase-sensitive) IR?
      • Wideband LGE?
      • T1 mapping?
      • Iron/T2*-mapping?
      • Edema/T2-mapping?
      • Why/how stress test?
      • Stess drugs/agents?
      • Stress consent form?
  • …MR Artifacts
    • Tissue-related artifacts >
      • Chemical shift artifact?
      • Chemical shift in phase?
      • Reducing chemical shift?
      • Chemical Shift 2nd Kind?
      • In-phase/out-of phase?
      • IR bounce point?
      • Susceptibility artifact?
      • Metal suppression?
      • Dielectric effect?
      • Dielectric Pads?
    • Motion-related artifacts >
      • Why discrete ghosts?
      • Motion artifact direction?
      • Reducing motion artifacts?
      • Saturation pulses?
      • Gating methods?
      • Respiratory comp?
      • Navigator echoes?
      • PROPELLER/BLADE?
    • Technique-related artifacts >
      • Partial volume effects?
      • Slice overlap?
      • Aliasing?
      • Wrap-around artifact?
      • Eliminate wrap-around?
      • Phase oversampling?
      • Frequency wrap-around?
      • Spiral/radial artifacts?
      • Gibbs artifact?
      • Nyquist (N/2) ghosts?
      • Zipper artifact?
      • Data artifacts?
      • Surface coil flare?
      • MRA Artifacts (TOF)?
      • MRA artifacts (CE)?
  • …Functional Imaging
    • Perfusion I: Intro & DSC >
      • Measuring perfusion?
      • Meaning of CBF, MTT etc?
      • DSC v DCE v ASL?
      • How to perform DSC?
      • Bolus Gd effect?
      • T1 effects on DSC?
      • DSC recirculation?
      • DSC curve analysis?
      • DSC signal v [Gd]
      • Arterial input (AIF)?
      • Quantitative DSC?
    • Perfusion II: DCE >
      • What is DCE?
      • How is DCE performed?
      • How is DCE analyzed?
      • Breast DCE?
      • DCE signal v [Gd]
      • DCE tissue parmeters?
      • Parameters to images?
      • K-trans = permeability?
      • Utility of DCE?
    • Perfusion III: ASL >
      • What is ASL?
      • ASL methods overview?
      • CASL?
      • PASL?
      • pCASL?
      • ASL parameters?
      • ASL artifacts?
      • Gadolinium and ASL?
      • Vascular color maps?
      • Quantifying flow?
    • Functional MRI/BOLD - I >
      • Who invented fMRI?
      • How does fMRI work?
      • BOLD contrast?
      • Why does BOLD ↑ signal?
      • Does BOLD=brain activity?
      • BOLD pulse sequences?
      • fMRI Paradigm design?
      • Why "on-off" comparison?
      • Motor paradigms?
      • Visual?
      • Language?
    • Functional MRI/BOLD - II >
      • Process/analyze fMRI?
      • Best fMRI software?
      • Data pre-processing?
      • Registration/normalization?
      • fMRI statistical analysis?
      • General Linear Model?
      • Activation "blobs"?
      • False activation?
      • Resting state fMRI?
      • Analyze RS-fMRI?
      • Network/Graphs?
      • fMRI at 7T?
      • Mind reading/Lie detector?
      • fMRI critique?
  • …MR Spectroscopy
    • MRS I - Basics >
      • MRI vs MRS?
      • Spectra vs images?
      • Chemical shift (δ)?
      • Measuring δ?
      • Backward δ scale?
      • Predicting δ?
      • Size/shapes of peaks?
      • Splitting of peaks?
      • Localization methods?
      • Single v multi-voxel?
      • PRESS?
      • STEAM?
      • ISIS?
      • CSI?
    • MRS II - Clinical ¹H MRS >
      • How-to: brain MRS?
      • Water suppression?
      • Fat suppression?
      • Normal brain spectra?
      • Choice of TR/TE/etc?
      • Hunter's angle?
      • Lactate inversion?
      • Metabolite mapping?
      • Metabolite quantitation?
      • Breast MRS?
      • Gd effect on MRS?
      • How-to: prostate MRS?
      • Prostate spectra?
      • Muscle ¹H-MRS?
      • Liver ¹H-MRS?
      • MRS artifacts?
    • MRS III - Multi-nuclear >
      • Other nuclei?
      • Why phosphorus?
      • How-to: ³¹P MRS
      • Normal ³¹P spectra?
      • Organ differences?
      • ³¹P measurements?
      • Decoupling?
      • NOE?
      • Carbon MRS?
      • Sodium imaging?
      • Xenon imaging?
  • ...Artificial Intelligence
    • AI Part I: Basics >
      • Artificial Intelligence (AI)?
      • What is a neural network?
      • Machine Learning (ML)?
      • Shallow v Deep ML?
      • Shallow networks?
      • Deep network types?
      • Data prep and fitting?
      • Back-Propagation?
      • DL 'Playground'?
    • AI Part 2: Advanced >
      • What is convolution?
      • Convolutional Network?
      • Softmax?
      • Upsampling?
      • Limitations/Problems of AI?
      • Is the Singularity near?
    • AI Part 3: Image processing >
      • AI in clinical MRI?
      • Super-resolution?
  • ...Tissue Properties Imaging
    • MRI of Hemorrhage >
      • Hematoma overview?
      • Types of Hemoglobin?
      • Hyperacute/Oxy-Hb?
      • Acute/Deoxy-Hb?
      • Subacute/Met-Hb?
      • Deoxy-Hb v Met-Hb?
      • Extracellular met-Hb?
      • Chronic hematomas?
      • Hemichromes?
      • Ferritin/Hemosiderin?
      • Subarachnoid blood?
      • Blood at lower fields?
    • T2 cartilage mapping
    • MR Elastography?
    • Synthetic MRI?
    • Amide Proton Transfer?
    • MR thermography?
    • Electric Properties Imaging?
  • Copyright/Legal
    • Copyright Issues
    • Legal Disclaimers
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  • What's New
  • Self-test Quizzes - NEW!
    • Magnets & Scanners Quiz
    • Safety & Screening Quiz
    • NMR Phenomenon Quiz
    • Pulse Sequences Quiz
    • Making an Image Quiz
    • K-space & Rapid Quiz
    • Contrast & Blood Quiz
    • Cardiovascular & MRA Quiz

Dipole-Dipole Interactions 

Can you explain a little more about the dipole-dipole interaction? I still don't quite understand. 
T1 and T2 relaxation; dipole-dipole interaction
 
The concept of the magnetic dipole has been introduced in a prior Q&A. In brief, protons, electrons, and NMR-active nuclei can be thought of as tiny magnets with north and south poles ("dipoles") whose electromagnetic fields interact through space. This interaction is called a dipole-dipole interaction is the most important single mechanism responsible for T1 and T2 relaxation in biological tissues. 
magnetic dipole
A spinning particle (proton, electron, or whole nucleus) modeled as a "dipole" that generates its own local magnetic field.
Four major factors determine the strength of the dipolar interaction: (1) types of spins; (2) the distance between them; (3) the angle between them; and (4) their relative motion.
Types of spins: Dipole-dipole interactions may be either proton-proton or proton-electron. Due to its small size, an electron has a much larger gyromagnetic ratio (γ) than a proton and so a proton-electron dipolar interaction is much more powerful than a proton-proton interaction. This is the reason paramagnetic substances like Gd+3 with multiple unpaired electrons are so effective at inducing magnetic relaxation.
T1 and T2 relaxation; dipole-dipole interaction

"Through-space" Interaction of magnetic fields from two spinning particles via the dipole-dipole mechanism.

Distance: The strength of the dipolar interaction depends on the distance between the spins. The effect is inversely proportional to the sixth power of distance (1/r6), explaining why short-range intramolecular dipole-dipole interactions are more powerful than long-range intermolecular ones. This generally means that two ¹H nuclei must approach within about 0.3 nm of each other to be effective at dipole-dipole interactions. If one of the dipoles is an electron or paramagnetic ion, then the distances up to 1 nm may still be effective. In pure water it is estimated that about 70% of the dipolar interactions are intramolecular while 30% are intermolecular.

Angle: The strength of the dipolar interaction also depends on the quantity (3 cos²θ −1), where θ is the angle between the two spins.  This leads to the interesting property that the static component of dipole-dipole interaction vanishes when θ ≈ 54.7°. This is the so-called magic angle, the value of θ that makes the term (3 cos²θ −1) = 0.  This phenomenon affects primarily T2 relaxation and explains why portions of tendons, nerves, and cartilage may have paradoxically high signal on routine musculoskeletal MR imaging if they make an angle of 54.7° with the main magnetic field. The details of this magic angle phenomenon will be described in a subsequent Q&A.
Relative motion: How the spins move relative to one another is a strong determinant of the degree and type of relaxation (combined T1/T2 or T2 alone). If one of the spins resides on a molecule that is tumbling or rotating at frequency ω, its associated dipolar field will also fluctuate at the same frequency. If that frequency happens to closely match the Larmor frequency, then conditions are optimal to cause T1 relaxation in a nearby spin.  Conversely, if the molecule on which the spin resides is hardly moving at all (as in large molecules fixed in cell membranes) the dipolar field will be relatively static, producing dephasing of nearby spins and predominantly T2 relaxation. 
 
A qualitative appreciation of how molecular motion of a dipolar pair causes locally fluctuating fields can be seen by considering the rotation of a water molecule (HOH) in the diagrams below. Each ¹H nucleus is a dipole generating its own localized magnetic field.  The magnitude of such local fields are quite small, on the order of ±7 gauss over typical intramolecular distances of 0.2-0.3 nm.

As the molecule rotates these local fields interact with one another. For ease of explanation let us assume that the light red ¹H nucleus remains stationary as the dark red ¹H nucleus rotates around it. As it rotates the dark red ¹H nucleus experiences a local field that fluctuates by ±7 gauss. The frequency of this local field fluctuation is directly related to the rate of molecular rotation.
dipole-dipole interaction
The local magnetic field near a hydrogen nucleus varies by ± 7 gauss (G) according to location.
dipole-dipole interaction
Dark red hydrogen nucleus experiences a magnetic field fluctuation of ±7G at a frequency determined by the molecular tumbling rate.

T1 and T2 relaxation; dipole-dipole interaction
T1 relaxation is most efficient at Larmor frequency (fo).
T1 Relaxation Effect. When this molecular "tumbling" rate is close to the Larmor frequency (fo), then the fluctuating magnetic field from one spin is optimal for inducing T1 relaxation in the other. The relationship between T1 and molecular tumbling rate is illustrated to the right. 

In this figure we see that water, with its small molecular size, tumbles much too rapidly in its free state to be effective at T1 relaxation.  T1 values are longer for free water than for any other substance in the body (approximately 4000 ms at 1.5T).  When the water is in a partially bound or in a restricted state, however, its tumbling may be slowed to a rate much closer to the Larmor frequency. Water molecules with restricted motion frequently occur in biological systems where their molecular motion is slowed by interaction with polar amide and hydroxyl groups on the surfaces of macromolecules. The T1 value of "bound" or "structured" water is therefore much shorter than that of free water (typically about 400-800 ms at 1.5T).  This is the type of water whose signal we primarily measure when imaging solid organs like the liver or brain. 

For completeness the graph shows that as molecular rotation rates slow below the Larmor frequency, the fluctuating dipolar fields are no longer efficient at inducing relaxation and T1 values again increase. If we measured the T1 value of ice, for example, as might form during a cryoablation procedure, we would find it to be very several seconds or more.  Ice has extremely long T1 values because in the crystalline state its molecular motions are much slower than the Larmor frequency.  Certain (non-biologic) solid crystals have been reported to have T1 values of weeks to months!

T2 Relaxation Effect. As the rate of molecular rotation falls below the Larmor frequency, local fields created by each spin fluctuate less and less and assume an increasingly static character. The z-component of a slowly fluctuating field (Bμz)  from one dipole (μ) augments or subtracts from the main field (Bo) at the site of the other dipole. The second dipole then precesses at a slightly lower or higher frequency, gaining or losing phase in the process.  This mechanism of dipolar interaction results in T2 relaxation without T1 relaxation. As the solid state is attained, all molecular rotations and translations largely cease and so the static mechanism predominates, resulting in very short T2 values.
T1 and T2 relaxation; dipole-dipole interaction
The z-component from one dipole (Bμz) adds to the Bo field at the second dipole, changing its precession frequency slightly. This results in T2 relaxation.
T1 and T2 relaxation; dipole-dipole interaction
The combined graph to the left shows how T2 relaxation time varies as a function of molecular tumbling rate. As expected, T2 becomes very short as the solid state is approached.  The small plateau in the T2 curve (accentuated in the diagram for didactic purposes) at the Larmor frequency represents the effect of T1 on T2 relaxation.

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More on Relaxation

References
     Bloembergen N, Purcell EM, Pound RV. Relaxation effects in nuclear magnetic resonance absorption. Phys Rev 1948;73(7):679-712. (The classic paper where the concepts of spin-lattice and spin-spin relaxation are developed formally as well as the recognition of inhomogeneity effects that we now call T2* but which the authors called T2').       
     Solomon I. Relaxation processes in a system of two spins. Phys Rev 1955; 99(1):559-565.
     Bloembergen N. Spin relaxation processes in a two-proton system. Phys Rev 1956;104(6):1542-1547.
     Bloembergen N, Morgan LO. Proton relaxation times in paramagnetic solutions. Effects of electron spin relaxation. J Chem Phys 1961; 14(3):842-850. This paper adds in paramagnetic effects.
     Goldman M. Formal theory of spin-lattice relaxation. J Magn Reson 2001; 149:160-187. (Heavy paper for advanced physicists only, but this has everything in it).

Related Questions
     Does the net magnetization (M) just instantly appear?  
     When a group of spins is driven into higher energy levels by the action of an RF field, why don't these spins immediately release the absorbed energy and drop back to their original lower energy states?  


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